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Qi RUI, Qin LU, Dayong WANG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 76-90 doi: 10.1007/s11684-009-0002-0

Abstract: During normal metabolism, oxidative byproducts will inevitably generate and damage molecules thereby impairing their biological functions, including the aging process. (补肾抗衰方, ) is a traditional Chinese medicine widely used for clinically treating premature ovarian failure. In the present study, administration at high concentrations significantly increased lifespan, slowed aging-related decline, and delayed accumulation of aging-related cellular damage in wild-type . administration could further largely alleviate the aging defects induced by UV and oxidative stresses, and administration at different concentrations could largely rescue the aging defects in mutant animals. The protective effects of administration on aging process were at least partially dependent on the Ins/IGF-like signaling pathway. Moreover, administration at different concentrations obviously altered the expression patterns of antioxidant genes and suppressed the severe stress responses induced by UV and oxidative stresses, suggesting that -induced tolerance to UV or oxidative stress might result from reactive oxygen species scavenging. administration during development was not necessarily a requirement for UV and oxidative stress resistance, and the concentrations of administrated examined were not toxic for nematodes. Therefore, administration could effectively retrieve the aging defects induced by UV irradiation and oxidative stress in .

Keywords： Bushenkangshuai Tang     UV irradiation     oxidative stress     tissue senescence     lifespan        

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Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 227-235 doi: 10.1007/s11684-014-0327-1

Abstract:

Accelerated senescence is important because this process is involved in tumor suppression and hasHowever, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinomaCellular senescence was then assessed by β-galactosidase assay.Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation.The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence

Keywords： reactive oxygen species     senescence     cisplatin     hepatocellular carcinoma    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract: Cellular senescence has been proposed as the mechanism that protects an organism against cancer progressionIn this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinomaThe strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectivelyCBX3 and senescence-associated β-galactosidase activity.Furthermore, Twist-induced senescence bypass is important in this process.

Keywords： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Atypical pituitary hormone–target tissue axis

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 1-17 doi: 10.1007/s11684-022-0973-7

Abstract: non-classical organs were summarized, defined by the novel concept of an “atypical pituitary hormone–target tissueThe continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could

Keywords： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophic hormone     prolactin    

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Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 267-276 doi: 10.1007/s11684-017-0586-8

Abstract: aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescenceHG-induced senescent cells showed the emergence of senescence associated heterochromatin foci, up-regulationof P16 and cyclin D1, increased senescence-associated β-galactosidase activity, and elevated expressionSKI treatment prevented HG-induced up-regulation of pro-senescence molecule mammalian target of rapamycinSKI may be a novel strategy for protecting against HG-induced renal tubular cell senescence in treatment

Keywords： Shenkang injection     senescence     renal tubular epithelial cells     diabetic nephropathy    

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Progress and perspectives of neural tissue engineering

Xiaosong Gu

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 401-411 doi: 10.1007/s11684-015-0415-x

Abstract: addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissueSeveral important aspects related to tissue engineered nerves, including the theory on their constructionFurthermore, potential research directions for the future development of neural tissue engineering are

Keywords： nerve injury     tissue engineering     nerve grafts    

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The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 6-10 doi: 10.1007/s11684-007-0002-x

Abstract: Much has been considerably developed recently in the ophthalmic research of stem cell (SC) and tissue

Keywords： available     observable     neuroregeneration     protection     function reconstruction    

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Decellularized extracellular matrix mediates tissue construction and regeneration

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 56-82 doi: 10.1007/s11684-021-0900-3

Abstract: Contributing to organ formation and tissue regeneration, extracellular matrix (ECM) constituents providetissue with three-dimensional (3D) structural integrity and cellular-function regulation.prompt stem-cell proliferation and differentiation for 3D organoid construction in vitro or tissueCellular ECM improves 3D culture development in vitro and tissue remodeling during wound healingGaining better insight into ECM derived from either tissue or cells that regulate 3D tissue reconstruction

Keywords： decellularized extracellular matrix     3D culture     organoids     tissue repair    

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Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 112-116 doi: 10.1007/s11684-010-0016-7

Abstract: conducted a trial to assess the influence of closure or nonclosure of the peritoneum and subcutaneous tissueResults showed that non-closure of the peritoneum and subcutaneous tissue could shorten operation timeOur study revealed that closure of the peritoneum and subcutaneous tissue provides no immediate postoperativeThe practice of closure of the peritoneum and subcutaneous tissue at radical hysterectomy should be questioned

Keywords： cervical cancer     radical surgery     peritoneum     subcutaneous tissue    

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Primary cilia in hard tissue development and diseases

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 657-678 doi: 10.1007/s11684-021-0829-6

Abstract: Hard tissue diseases have a serious effect on human survival and quality of life.mutations present overt changes in the skeletal system, suggesting that primary cilia are involved in hard tissuethrough primary cilia by intraflagellar transport, which affects key signaling pathways during hard tissueIn addition, the cilium-related diseases of hard tissue and the manifestations of mutant cilia in theWe believe that all the findings will help with the intervention and treatment of related hard tissue

Keywords： primary cilia     bone     mechanical sensing     hard tissue     cilium-related bone disease     tooth    

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Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 490-495 doi: 10.1007/s11684-018-0647-7

Abstract:

Identification of the driver mutations in cancer has resulted in the development of a new category of molecularly targeted anti-cancer drugs. However, as was the case with conventional chemotherapies, the effectiveness of these drugs is limited by the emergence of drug-resistant variants. While most cancer therapies are given in combinations that are designed to avoid drug resistance, we discuss here therapeutic approaches that take advantage of the changes in cancer cells that arise upon development of drug resistance. This approach is based on notion that drug resistance comes at a fitness cost to the cancer cell that can be exploited for therapeutic benefit. We discuss the development of sequential drug therapies in which the first therapy is not given with curative intent, but to induce a major new sensitivity that can be targeted with a second drug that selectively targets the acquired vulnerability. This concept of collateral sensitivity has hitherto not been used on a large scale in the clinic and holds great promise for future cancer therapy.

Keywords： cancer     drug resistance     genetic screens     senescence     targeted therapy    

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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract: of organs, known as the stem cell niche, which is recognized to have an important role in regulating tissueIn wound healing and tissue repair, stem cells are mobilized and recruited to the site of wound, andHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,

Keywords： stem cell     stem cell niche     electric field     tissue repair    

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Microorganism-derived biological macromolecules for tissue engineering

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 358-377 doi: 10.1007/s11684-021-0903-0

Abstract: materials from live creatures as new sources to produce innovative smart biomaterials for increasing tissuereconstruction in tissue engineering and regenerative medicine.such as pullulan, alginate, dextran, curdlan, and hyaluronic acid, and their available sources for tissue

Keywords： biological macromolecules     regenerative medicine     tissue engineering     exopolysaccharide     carbohydrate    

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Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 415-420 doi: 10.1007/s11684-009-0072-z

Abstract: aim of this study was to investigate the inhibitory effects of recombinant adenovirus vector carrying tissue

Keywords： tissue inhibitor of metalloproteinase-3     intervertebral disc     rabbit     gene therapy    

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Advances in tissue state recognition in spinal surgery: a review

Hao Qu, Yu Zhao

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 575-584 doi: 10.1007/s11684-020-0816-3

Abstract: the past, tactile sensation was the primary method used by surgeons to understand the state of the tissueTherefore, it has become the focus of spinal surgery research so as to strengthen the objectivity of tissueThis article reviews the progress of different tissue state recognition methods in spinal surgery and

Keywords： spinal surgery     tissue state recognition     image     force sensing     bioelectrical impedance    

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Title Author Date Type Operation

Administration with

Qi RUI, Qin LU, Dayong WANG

Journal Article

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Atypical pituitary hormone–target tissue axis

Journal Article

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Journal Article

Progress and perspectives of neural tissue engineering

Xiaosong Gu

Journal Article

The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Journal Article

Decellularized extracellular matrix mediates tissue construction and regeneration

Journal Article

Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

Journal Article

Primary cilia in hard tissue development and diseases

Journal Article

Taking advantage of drug resistance, a new approach in the war on cancer

Liqin Wang, Rene Bernards

Journal Article

Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Journal Article

Microorganism-derived biological macromolecules for tissue engineering

Journal Article

Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Journal Article

Advances in tissue state recognition in spinal surgery: a review

Hao Qu, Yu Zhao

Journal Article